Structure of PDB 3hvl Chain B

Receptor sequence
>3hvlB (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
VQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQV
RKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFK
GIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECG
RLSYCLEQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQH
RVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQ
RLLRIQDIHPFATPLMQELFGISLTERHKILHRLLQEGS
3D structure
PDB3hvl Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRL B M243 S247 F281 Q285 W299 Y306 M323 H327 H407 L411 F420 F429 M91 S95 F129 Q133 W147 Y154 M164 H168 H248 L252 F261 F270
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3hvl, PDBe:3hvl, PDBj:3hvl
PDBsum3hvl
PubMed18456871
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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