Structure of PDB 3hu3 Chain B

Receptor sequence
>3hu3B (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]
LKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRRE
AVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHV
LPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVHGGMRAVEFKVV
ETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQI
KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFF
FLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT
HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDRE
VDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCS
EAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPS
3D structure
PDB3hu3 A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
ChainB
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS B G207 P247 G248 T249 G250 K251 T252 L253 N348 I380 H384 G408 A409 G191 P231 G232 T233 G234 K235 T236 L237 N332 I364 H368 G392 A393 MOAD: Kd=0.13uM
PDBbind-CN: -logKd/Ki=6.89,Kd=0.13uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:3hu3, PDBe:3hu3, PDBj:3hu3
PDBsum3hu3
PubMed20512113
UniProtP55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

[Back to BioLiP]