Structure of PDB 3hrk Chain B

Receptor sequence
>3hrkB (length=413) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
VETEPVQGCRDFPPEAMRCRRHLFDVFHATAKTFGFEEYDAPVLESEELY
IRKAGEEITEQMFNFITHRVALRPEMTPSLARLLLGKGRSLLLPAKWYSI
PQCWRYEAITRGRRREHYQWNMDIVGVKSVSAEVELVCAACWAMRSLGLS
SKDVGIKVNSRKVLQTVVEQAGVTSDKFAPVCVIVDKMEKIPREEVEAQL
AVLGLEPTVVDAITTTLSLKSIDEIAQRVGEEHEAVKELRQFFEQVEAYG
YGDWVLFDASVVRGLAYYTGIVFEGFDREGKFRALCGGGRYDNLLTTYGS
PTPIPCAGFGFGDCVIVELLQEKRLLPDIPHVVDDVVIPFDESMRPHALA
VLRRLRDAGRSADIILDKKKVVQAFNYADRVGAVRAVLVAPEEWERGEVQ
VKMLFAVPLDRLV
3D structure
PDB3hrk Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
ChainB
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HAM B E126 T128 R156 G163 R164 H168 Q170 R314 L316 Y318 Y319 A335 L336 C337 G338 G359 G363 E75 T77 R105 G112 R113 H117 Q119 R263 L265 Y267 Y268 A284 L285 C286 G287 G308 G312
Gene Ontology
Molecular Function
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hrk, PDBe:3hrk, PDBj:3hrk
PDBsum3hrk
PubMed20132829
UniProtQ4DA54

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