Structure of PDB 3hq5 Chain B

Receptor sequence
>3hq5B (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
QLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVK
WSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPD
LILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIP
LEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLH
DLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH
K
3D structure
PDB3hq5 Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GKK B L718 N719 L721 Q725 M756 M759 F778 M801 L887 Y890 C891 F905 L37 N38 L40 Q44 M75 M78 F97 M120 L206 Y209 C210 F224 MOAD: ic50=16nM
BindingDB: IC50=16nM,EC50=9nM
External links
PDB RCSB:3hq5, PDBe:3hq5, PDBj:3hq5
PDBsum3hq5
PubMed19595590
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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