Structure of PDB 3hm8 Chain B

Receptor sequence

>3hm8B (length=441) Species: 9606 (Homo sapiens)

SRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRA
TPDGSERGDFLALDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQ
QLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKG
FKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRC
EIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLS
TRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQ
IQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEV
CQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFS
SLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRLAQ

3D structure

• PDB: 3hm8 Crystal structure of the C-terminal Hexokinase domain of human HK3
• Chain: B
• Resolution: 2.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R549 S609 N624 D663
• Catalytic site (residue number reindexed from 1): R71 S131 N146 D185
• Enzyme Commision number: 2.7.1.1: hexokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	B	S609 F610 T626 K627 N662 D663 G687 N689 E714 E748	S131 F132 T148 K149 N184 D185 G209 N211 E236 E270
BS02	BG6	B	D542 T546 D663 G685 T686 D867 T869 S903	D64 T68 D185 G207 T208 D389 T391 S425

Gene Ontology

Molecular Function

• GO:0004396 hexokinase activity
• GO:0005524 ATP binding
• GO:0005536 D-glucose binding
• GO:0016773 phosphotransferase activity, alcohol group as acceptor

Biological Process

• GO:0001678 intracellular glucose homeostasis
• GO:0005975 carbohydrate metabolic process
• GO:0006096 glycolytic process

External links

• PDB: RCSB:3hm8, PDBe:3hm8, PDBj:3hm8
• PDBsum: 3hm8
• UniProt: P52790|HXK3_HUMAN Hexokinase-3 (Gene Name=HK3)