Structure of PDB 3hkj Chain B

Receptor sequence
>3hkjB (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSAGAGCDRKYGFYTHVFRLKKWIQKVIDQF
GE
3D structure
PDB3hkj Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E197 G198 D199 S200 G201
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F34 L40 L65 R67 R73 T74 R75 Y76 I82 M84 F19 L26 L60 R62 R68 T69 R70 Y71 I78 M80
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3hkj, PDBe:3hkj, PDBj:3hkj
PDBsum3hkj
PubMed19586901
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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