Structure of PDB 3hk2 Chain B

Receptor sequence
>3hk2B (length=666) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVL
DLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE
LLRLGEEDPKELPLPSLLDYHASKGRLQGREGGRVAWVADPKDPRKPIPH
LTGLLVPVLTLESLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLS
IPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLR
AFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWED
RNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSG
AYPAELAVGFNAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQE
VVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIA
YDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRRGTPRPLKL
VHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRL
GIRHLKEVDREKLFFV
3D structure
PDB3hk2 Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.24.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hk2, PDBe:3hk2, PDBj:3hk2
PDBsum3hk2
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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