Structure of PDB 3hd3 Chain B

Receptor sequence
>3hd3B (length=214) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLAE
QMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPP
CTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGG
VMTSCVSEQLDHGVLLVGYNDGAAVPYWIIKNSWTTQWGEEGYIRIAKGS
NQCLVKEEASSAVV
3D structure
PDB3hd3 Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.51: cruzipain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25B B Q19 G23 C25 G65 G66 L67 M145 D161 H162 W184 Q19 G23 C25 G65 G66 L67 M145 D161 H162 W184
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3hd3, PDBe:3hd3, PDBj:3hd3
PDBsum3hd3
PubMed19773167
UniProtP25779|CYSP_TRYCR Cruzipain

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