Structure of PDB 3h73 Chain B

Receptor sequence
>3h73B (length=477) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
LPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADER
RLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNI
DMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYR
EGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLG
NIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFL
GVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTW
HAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLT
GDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNA
GGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGIL
YEHTEKGQNAYTLSFRKFNWDFLSKDL
3D structure
PDB3h73 Crystal structures of respiratory pathogen neuraminidases
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S371 D372 E647 Y752
Catalytic site (residue number reindexed from 1) S55 D56 E331 Y436
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DAN B R347 I348 D372 I416 D417 F443 Y590 Q602 R663 R721 Y752 R31 I32 D56 I100 D101 F127 Y274 Q286 R347 R405 Y436
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:3h73, PDBe:3h73, PDBj:3h73
PDBsum3h73
PubMed19284989
UniProtP62576|NANA_STRR6 Sialidase A (Gene Name=nanA)

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