Structure of PDB 3h6v Chain B

Receptor sequence
>3h6vB (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKNK
WWYKGECG
3D structure
PDB3h6v Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NS6 B I92 S217 K218 I89 S214 K215
BS02 GLU B Y61 L90 T91 R96 G141 S142 T143 E193 Y58 L87 T88 R93 G138 S139 T140 E190
BS03 NS6 B P105 M107 S108 S242 P102 M104 S105 S239
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3h6v, PDBe:3h6v, PDBj:3h6v
PDBsum3h6v
PubMed19591837
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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