Structure of PDB 3h55 Chain B

Receptor sequence
>3h55B (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
LDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMADRMAQDGW
RDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLG
IYADMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQ
GYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVQYSLLADICNLWRNYDD
IQDSWWSVLSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSR
AQMALWTVLAAPLLMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRI
HKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNFTGSVIYE
AQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIK
3D structure
PDB3h55 The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases
ChainB
Resolution1.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 D217
Catalytic site (residue number reindexed from 1) D139 D200
Enzyme Commision number 3.2.1.49: alpha-N-acetylgalactosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLA B W33 D78 D79 C127 K154 D156 R213 D217 W16 D61 D62 C110 K137 D139 R196 D200
BS02 GLA B A191 Y192 D217 A174 Y175 D200
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004557 alpha-galactosidase activity
GO:0008456 alpha-N-acetylgalactosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042803 protein homodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006629 lipid metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0016052 carbohydrate catabolic process
GO:0016139 glycoside catabolic process
GO:0019377 glycolipid catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3h55, PDBe:3h55, PDBj:3h55
PDBsum3h55
PubMed19683538
UniProtP17050|NAGAB_HUMAN Alpha-N-acetylgalactosaminidase (Gene Name=NAGA)

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