Structure of PDB 3h52 Chain B

Receptor sequence
>3h52B (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKW
AKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDL
IINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPK
DGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHE
VVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3h52 Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V575 K579 M593 E755 N759 V48 K52 M66 E228 N232
BS02 486 B M560 L563 N564 G567 Q570 M604 Q642 M646 Y735 L753 M33 L36 N37 G40 Q43 M77 Q115 M119 Y208 L226 BindingDB: IC50=1.1nM,Ki=1.2nM,EC50=872nM,Kd=15nM
External links
PDB RCSB:3h52, PDBe:3h52, PDBj:3h52
PDBsum3h52
PubMed19913032
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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