Structure of PDB 3h1p Chain B

Receptor sequence
>3h1pB (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
YQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFD
VIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVT
PIKDLTAHFRGDRSKTLLEKPKLFFIQACRGTELDDGIQYKAPVEADFLF
AYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVAR
HFESQSDDPHFHEKKQIPCVVSMLTKELYFSQH
3D structure
PDB3h1p L2' loop is critical for caspase-7 active site formation.
ChainB
Resolution2.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G28 V29 H87 G88 C129
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R87 H144 Q184 C186 Y230 S231 W232 R233 S234 P235 Q276 R30 H87 Q127 C129 Y159 S160 W161 R162 S163 P164 Q205
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3h1p, PDBe:3h1p, PDBj:3h1p
PDBsum3h1p
PubMed19530232
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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