Structure of PDB 3h11 Chain B

Receptor sequence
>3h11B (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTT
TFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI
IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQQTRYIP
DEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILT
EVNYEVSNKGKQMPQPTFTLRKKLVFPSD
3D structure
PDB3h11 Mechanism of procaspase-8 activation by c-FLIPL.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R243 D244 H302 G303 C345 Q346
Catalytic site (residue number reindexed from 1) R36 D37 H95 G96 C138 Q139
Enzyme Commision number 3.4.22.61: caspase-8.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R243 R245 H302 C345 S396 Y397 R398 P400 R36 R38 H95 C138 S167 Y168 R169 P171
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3h11, PDBe:3h11, PDBj:3h11
PDBsum3h11
PubMed19416807
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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