Structure of PDB 3h0w Chain B

Receptor sequence
>3h0wB (length=61) Species: 9606 (Homo sapiens) [Search protein sequence]
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTK
TDKQEAYVLSE
3D structure
PDB3h0w Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
ChainB
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E67
Catalytic site (residue number reindexed from 1) E61
Enzyme Commision number 4.1.1.50: adenosylmethionine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N8M B F7 S66 E67 F4 S60 E61 PDBbind-CN: -logKd/Ki=6.22,IC50=600nM
BindingDB: IC50=600nM
BS02 PYR B V64 L65 V58 L59
Gene Ontology
Molecular Function
GO:0004014 adenosylmethionine decarboxylase activity
Biological Process
GO:0008295 spermidine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3h0w, PDBe:3h0w, PDBj:3h0w
PDBsum3h0w
PubMed19527050
UniProtP17707|DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (Gene Name=AMD1)

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