Structure of PDB 3h0v Chain B

Receptor sequence
>3h0vB (length=58) Species: 9606 (Homo sapiens) [Search protein sequence]
HFFEGTEKLLEVWFSRQQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDK
QEAYVLSE
3D structure
PDB3h0v Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
ChainB
Resolution2.24 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E67
Catalytic site (residue number reindexed from 1) E58
Enzyme Commision number 4.1.1.50: adenosylmethionine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M2T B F7 S66 E67 F3 S57 E58 PDBbind-CN: -logKd/Ki=4.82,IC50=15uM
Gene Ontology
Molecular Function
GO:0004014 adenosylmethionine decarboxylase activity
Biological Process
GO:0008295 spermidine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3h0v, PDBe:3h0v, PDBj:3h0v
PDBsum3h0v
PubMed19527050
UniProtP17707|DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (Gene Name=AMD1)

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