Structure of PDB 3gw5 Chain B

Receptor sequence
>3gw5B (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSR
LYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGIT
VTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVL
KEDVFSFYYNRDSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGV
SVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVK
CNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPP
TGPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB3gw5 Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D38 S41 N43 W45 Y83 D226 A229
Catalytic site (residue number reindexed from 1) D35 S38 N40 W42 Y80 D218 A221
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 72X B T18 Q19 Y20 D38 G40 Y83 T85 P118 F119 F124 D226 G228 S230 T15 Q16 Y17 D35 G37 Y80 T82 P115 F116 F121 D218 G220 S222 MOAD: ic50=0.47nM
BindingDB: IC50=0.47nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3gw5, PDBe:3gw5, PDBj:3gw5
PDBsum3gw5
PubMed19457666
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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