Structure of PDB 3gt9 Chain B

Receptor sequence
>3gt9B (length=89) Species: 9606 (Homo sapiens) [Search protein sequence]
GPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTDKVRCFFCYGG
LQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIHLT
3D structure
PDB3gt9 Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F81
Catalytic site (residue number reindexed from 1) F4
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C124 C127 H144 C151 C44 C47 H64 C71
BS02 516 B K121 R123 G130 L131 Q132 S133 W134 D138 E143 W147 K41 R43 G50 L51 Q52 S53 W54 D58 E63 W67 BindingDB: Ki=110000nM
External links
PDB RCSB:3gt9, PDBe:3gt9, PDBj:3gt9
PDBsum3gt9
PubMed20189383
UniProtQ96CA5|BIRC7_HUMAN Baculoviral IAP repeat-containing protein 7 (Gene Name=BIRC7)

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