Structure of PDB 3gqc Chain B

Receptor sequence

>3gqcB (length=440) Species: 9606 (Homo sapiens)

SDCNFISNFYSHSRLHHISMWKCELTEFVNTLQRQSNGIFPGREKLKKMQ
SCIMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLE
WQYYQNKANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQA
VPYDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPD
EFANAVRMEIKDQTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVD
DFIRGQLVTNLPGVGHSMESKLASLGIKTCGDLQYMTMAKLQKEFGPKTG
QMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEE
IQRRLEATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNIARTVTLDQ
ATDNAKIIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPTN

3D structure

• PDB: 3gqc Structure of the human Rev1-DNA-dNTP ternary complex.
• Chain: B
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	S568 R618 G651 V652 G653 S655 M656 R752 T783	S180 R230 G263 V264 G265 S267 M268 R364 T395
BS02	dna	B	F352 Y353 H355 S356 R357 L358 H359 S362 S448 S504 R505 A506 P685 K686 T687 R709 K710 S713 A714 E715 N717 Y718 R742 K770 F771 G773 H774	F9 Y10 H12 S13 R14 L15 H16 S19 S82 S116 R117 A118 P297 K298 T299 R321 K322 S325 A326 E327 N329 Y330 R354 K382 F383 G385 H386
BS03	DCP	B	R357 M424 C426 F427 F428 A509 S510 Y513 R516 N522 D570 K625	R14 M58 C60 F61 F62 A121 S122 Y125 R128 N134 D182 K237
BS04	MG	B	D423 M424 D570	D57 M58 D182
BS05	MG	B	T647 N648 L649	T259 N260 L261

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:3gqc, PDBe:3gqc, PDBj:3gqc
• PDBsum: 3gqc
• PubMed: 19464298
• UniProt: Q9UBZ9|REV1_HUMAN DNA repair protein REV1 (Gene Name=REV1)