Structure of PDB 3gpo Chain B

Receptor sequence
>3gpoB (length=160) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
APSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSAT
PVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLG
VNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEK
KISEAIQMRT
3D structure
PDB3gpo The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
ChainB
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR B D10 I11 A22 D31 G32 V33 L108 S110 T111 G112 V113 Y114 R144 D10 I11 A22 D31 G32 V33 L108 S110 T111 G112 V113 Y114 R144 MOAD: Kd=5uM
External links
PDB RCSB:3gpo, PDBe:3gpo, PDBj:3gpo
PDBsum3gpo
PubMed19386706
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

[Back to BioLiP]