Structure of PDB 3gni Chain B

Receptor sequence
>3gniB (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
AHHHHHHMENLYFQSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGE
YVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWV
VTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRS
VKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLS
PEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKFSPH
FHHFVEQCLQRNPDARPSASTLLNHSFFKQIASEALPELLRPVTPITEVD
DWEF
3D structure
PDB3gni ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor
ChainB
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S195 K197 H200 G213 F233
Catalytic site (residue number reindexed from 1) S150 K152 H155 G168 F188
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B I75 G78 F79 M83 T98 R100 M150 D157 S199 H200 L202 R215 I30 G33 F34 M38 T53 R55 M105 D112 S154 H155 L157 R170 MOAD: Kd=0.02uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3gni, PDBe:3gni, PDBj:3gni
PDBsum3gni
PubMed19513107
UniProtQ7RTN6|STRAA_HUMAN STE20-related kinase adapter protein alpha (Gene Name=STRADA)

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