Structure of PDB 3gn8 Chain B

Receptor sequence
>3gn8B (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
APTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEM
VGGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQK
3D structure
PDB3gn8 An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
ChainB
Resolution2.5 Å
3D
structure
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Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide B V44 K48 R54 M62 Q66 M221 E224 N228 V47 K51 R57 M65 Q69 M224 E227 N231
BS02 DEX B L32 N33 Q39 M70 M73 F92 Q111 C205 T208 L35 N36 Q42 M73 M76 F95 Q114 C208 T211
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