Structure of PDB 3gic Chain B

Receptor sequence
>3gicB (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKGQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB3gic Stabilization of the E* form turns thrombin into an anticoagulant.
ChainB
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E193 G194 D195 S196 G197
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 G136 R137 N159 M201 K202 N205 R206 W207 E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 G136 R137 N155 M202 K203 N208 R209 W210
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3gic, PDBe:3gic, PDBj:3gic
PDBsum3gic
PubMed19473969
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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