Structure of PDB 3ghh Chain B

Receptor sequence
>3ghhB (length=237) Species: 9913 (Bos taurus) [Search protein sequence]
LNRWHGAGSTADFQKIIQERCDTYTQTIRPGSRSRNCQAIRQAFMSAFIS
KDPCKATKEDYNSLINLAPPTVPCGQQVFWSKTKELAHEYAKRRRLMTLE
DTLLGYLADGLRWCGEPGSSDLNIWSCPDWRKDCRTNYLSVFWEVLSERF
AESACNTVRVVLNGSLENAFDSMSIFGRVQAPNLRPQVELEAWLVHDTGK
PPSDSCSGSSIRKLKSILDGRNVKFRCMDNLSRDQFL
3D structure
PDB3ghh Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
ChainB
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E138 I213 Q218
Catalytic site (residue number reindexed from 1) E100 I175 Q180
Enzyme Commision number 2.4.99.20: 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase.
3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NF B W118 S119 K120 L137 E138 W168 S178 W181 S212 I213 F214 R216 Q218 W80 S81 K82 L99 E100 W130 S140 W143 S174 I175 F176 R178 Q180
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3ghh, PDBe:3ghh, PDBj:3ghh
PDBsum3ghh
PubMed22529956
UniProtQ9TTF5

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