Structure of PDB 3gdl Chain B

Receptor sequence
>3gdlB (length=257) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TYKERAATHPSPVAAKLFNIMHEKQTNLCASLDVRTTKELLELVEALGPK
ICLLKTHVDILTDFSMEGTVKPLKALSAKYNFLLFEDRKFADIGNTVKLQ
YSAGVYRIAEWADITNAHGVVGPGIVSGLKQAAEEVTKEPRGLLMLAELS
CKGSLATGEYTKGTVDIAKSDKDFVIGFIAQRDMGGRDEGYDWLIMTPGV
GLDDKGDALGQQYRTVDDVVSTGSDIIIVGRGLFAKGRDAKVEGERYRKA
GWEAYLR
3D structure
PDB3gdl Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UP6 B D96 I97 T100 D92 I93 T96 BindingDB: Ki=64nM
BS02 UP6 B S35 D37 K59 H61 K93 L153 S154 P202 Q215 Y217 G234 R235 S31 D33 K55 H57 K89 L149 S150 P198 Q211 Y213 G230 R231 BindingDB: Ki=64nM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3gdl, PDBe:3gdl, PDBj:3gdl
PDBsum3gdl
PubMed19435314
UniProtP03962|PYRF_YEAST Orotidine 5'-phosphate decarboxylase (Gene Name=URA3)

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