Structure of PDB 3gdh Chain B

Receptor sequence
>3gdhB (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
EIAAVPELAKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVS
QSCDVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIA
DKIEFICGDFLLLASFLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGF
EIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTI
TAYFGDLIR
3D structure
PDB3gdh Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MGP B K646 F670 S671 V672 S763 P764 W766 Y771 R807 K836 K10 F34 S35 V36 S125 P126 W128 Y133 R169 K198
BS02 SAH B S671 V672 F698 C699 V701 G703 N704 D719 I720 D747 F748 S763 P765 S35 V36 F60 C61 V63 G65 N66 D81 I82 D109 F110 S125 P127
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0036261 7-methylguanosine cap hypermethylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3gdh, PDBe:3gdh, PDBj:3gdh
PDBsum3gdh
PubMed19386620
UniProtQ96RS0|TGS1_HUMAN Trimethylguanosine synthase (Gene Name=TGS1)

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