Structure of PDB 3gd7 Chain B

Receptor sequence
>3gd7B (length=377) Species: 9606,83333 [Search protein sequence]
IWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKST
LLSAFLRLLNTEGEIQIDGVSWDSITLEQWRKAFGVIPQKVFIFSGTFRK
NLDPNAAHSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQ
LMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEA
RIEAMLECDQFLVIEENKVRQYDSILELYHYPADRFVAGFIGSPKMNFLP
VKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPS
DIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATF
AIGLPPERCHLFREDGTACRRLHKEPG
3D structure
PDB3gd7 Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
ChainB
Resolution2.7 Å
3D
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
7.5.2.1: ABC-type maltose transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B44 B Y1219 T1246 G1247 G1249 K1250 S1251 T1252 Y17 T44 G45 G47 K48 S49 T50
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0043190 ATP-binding cassette (ABC) transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3gd7, PDBe:3gd7, PDBj:3gd7
PDBsum3gd7
PubMed
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR);
P68187|MALK_ECOLI Maltose/maltodextrin import ATP-binding protein MalK (Gene Name=malK)

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