Structure of PDB 3g8e Chain B

Receptor sequence
>3g8eB (length=463) Species: 10116 (Rattus norvegicus) [Search protein sequence]
FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFYGLQYILNKYL
KGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVP
EGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKK
ILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT
VAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFS
SVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDT
VLKVLDILGKKFPVSENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQ
KKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVAD
PNKRSKKGRLSLHRTPAGTFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKS
YSFDEVRKNAQLN
3D structure
PDB3g8e Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.12: nicotinamide phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IS1 B D16 Y18 D8 Y10 PDBbind-CN: -logKd/Ki=5.35,Kd=4.5uM
BS02 IS1 B Y188 F193 D219 V242 A244 S275 I309 R311 D313 R349 E376 N377 S379 Y168 F173 D199 V222 A224 S255 I289 R291 D293 R329 E356 N357 S359 PDBbind-CN: -logKd/Ki=5.35,Kd=4.5uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005125 cytokine activity
GO:0016757 glycosyltransferase activity
GO:0042802 identical protein binding
GO:0047280 nicotinamide phosphoribosyltransferase activity
GO:1901363 heterocyclic compound binding
Biological Process
GO:0001774 microglial cell activation
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007623 circadian rhythm
GO:0008286 insulin receptor signaling pathway
GO:0009435 NAD biosynthetic process
GO:0010507 negative regulation of autophagy
GO:0014070 response to organic cyclic compound
GO:0014916 regulation of lung blood pressure
GO:0019363 pyridine nucleotide biosynthetic process
GO:0032922 circadian regulation of gene expression
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060612 adipose tissue development
GO:0071456 cellular response to hypoxia
GO:0071479 cellular response to ionizing radiation
GO:1904646 cellular response to amyloid-beta
GO:1905377 response to D-galactose
GO:2000773 negative regulation of cellular senescence
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3g8e, PDBe:3g8e, PDBj:3g8e
PDBsum3g8e
PubMed19533035
UniProtQ80Z29|NAMPT_RAT Nicotinamide phosphoribosyltransferase (Gene Name=Nampt)

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