Structure of PDB 3g4t Chain B

Receptor sequence
>3g4tB (length=255) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence]
MAVLKIISWNVNGLRAVHRKGFLKWFMEEKPDILCLQEIKAAPEQLPRKL
RHVEGYRSFFTPAERKGYSGVAMYTKVPPSSLREGFGVERFDTEGRIQIA
DFDDFLLYNIYFPNGKMSEERLKYKLEFYDAFLEDVNRERDSGRNVIICG
DFNTAHREIDLARPKENSNVSGFLPVERAWIDKFIENGYVDTFRMFNSDP
GQYTWWSYRTRARERNVGWRLDYFFVNEEFKGKVKRSWILSDVMGSDHCP
IGLEI
3D structure
PDB3g4t Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA
ChainB
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N10 N12 E38 Y111 D151 N153 D222 D247 H248
Catalytic site (residue number reindexed from 1) N10 N12 E38 Y111 D151 N153 D222 D247 H248
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B N12 G13 R15 A16 K20 K40 Q45 K66 Y208 R209 N12 G13 R15 A16 K20 K40 Q45 K66 Y208 R209
BS02 dna B E38 R65 Y68 M117 R209 E38 R65 Y68 M117 R209
BS03 MG B N12 E38 D247 H248 N12 E38 D247 H248
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3g4t, PDBe:3g4t, PDBj:3g4t
PDBsum3g4t
PubMed20434457
UniProtO26314|UREND_METTH DNA uridine endonuclease (Gene Name=MTH_212)

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