Structure of PDB 3g4c Chain B

Receptor sequence
>3g4cB (length=211) Species: 2336 (Thermotoga maritima) [Search protein sequence]
HMKIDILDKGFVELVDVMGNDLSAVRAARVSRDRHLIEYLMKHGHETPFE
HIVFTFHVKAPIFVARQWFRHRIASYNELCGRYSKLSYEFYIPSPERLEG
YKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRF
FWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKY
AYKGDILKEVQ
3D structure
PDB3g4c An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B E86 C88 G89 R90 R147 E78 C80 G81 R82 R139
BS02 FAD B R78 H79 R80 I81 N169 L173 R174 H178 R70 H71 R72 I73 N161 L165 R166 H170
BS03 FAD B N85 E86 C88 N77 E78 C80
BS04 UMP B Q75 R78 R174 Q67 R70 R166
BS05 FAD B T55 E58 I81 N163 R165 T47 E50 I73 N155 R157
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3g4c, PDBe:3g4c, PDBj:3g4c
PDBsum3g4c
PubMed19370033
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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