Structure of PDB 3g4a Chain B

Receptor sequence
>3g4aB (length=220) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLM
KHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELAGRYSKLSYEFY
IPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIV
LPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCP
WTFEAFLKYAYKGDILKEVQ
3D structure
PDB3g4a An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
ChainB
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B E86 A88 G89 R90 R147 E87 A89 G90 R91 R148
BS02 FAD B R78 H79 R80 I81 N169 L173 R174 H178 R79 H80 R81 I82 N170 L174 R175 H179
BS03 FAD B N85 E86 N86 E87
BS04 UMP B Q75 R78 R174 Q76 R79 R175
BS05 FAD B S30 T55 E58 I81 N163 R165 S31 T56 E59 I82 N164 R166
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3g4a, PDBe:3g4a, PDBj:3g4a
PDBsum3g4a
PubMed19370033
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

[Back to BioLiP]