Structure of PDB 3g3d Chain B

Receptor sequence
>3g3dB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
APKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLA
DALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGN
TVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAE
MSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAA
WEAYLSRLG
3D structure
PDB3g3d Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.10: orotate phosphoribosyltransferase.
4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5FU B D128 I129 T132 D97 I98 T101 PDBbind-CN: -logKd/Ki=4.74,Ki=18.2uM
BindingDB: Ki=98000nM
BS02 5FU B S68 D70 H94 K125 M182 S183 P228 Q241 Y243 G261 R262 S37 D39 H63 K94 M151 S152 P197 Q210 Y212 G230 R231 PDBbind-CN: -logKd/Ki=4.74,Ki=18.2uM
BindingDB: Ki=98000nM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3g3d, PDBe:3g3d, PDBj:3g3d
PDBsum3g3d
PubMed19260677
UniProtP11172|UMPS_HUMAN Uridine 5'-monophosphate synthase (Gene Name=UMPS)

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