Structure of PDB 3fz0 Chain B

Receptor sequence
>3fz0B (length=338) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
VHRKLIIDTDCGGDDAIAIMLAMTQPDVEVIAITVVWGNVEVNQGMENIG
KLLDLYDADIPFFRGAEGPLVGERETVQWGGFGSDGFGDAGFPPSQRVAL
QPKRHAALEILKILEEAEPSDDVVYQLVALGPLTNVALALRLNPDLFSKL
GTDTIPGIVIMNGTSESKGNSNMAAEFNSHCDPEAGVVVLQHKGWKCPVQ
LVNWEVTVNSPMTWGFYDKLVNRESTPNGRVAVNQNKWQEFIEKLFQRLE
AFTRVTCVVPDAVAVLVAIRPESVLDSFLTYVTVELHGRETRGATCIDWY
GTEQSMAKKGRWRNCNVITKVDNEMFLKALRDIVEYVA
3D structure
PDB3fz0 Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D11 D16 N40 L131 F178 N179 P279 D280
Catalytic site (residue number reindexed from 1) D10 D15 N39 L130 F177 N178 P260 D261
Enzyme Commision number 3.2.2.1: purine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D11 D16 L131 D280 D10 D15 L130 D261
Gene Ontology
Molecular Function
GO:0008477 purine nucleosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872 metal ion binding
GO:0047724 inosine nucleosidase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006179 guanosine salvage
GO:0006190 inosine salvage
Cellular Component
GO:0005737 cytoplasm
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fz0, PDBe:3fz0, PDBj:3fz0
PDBsum3fz0
PubMed20825170
UniProtQ57X73

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