Structure of PDB 3fvs Chain B

Receptor sequence
>3fvsB (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
QLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHA
VSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGA
LFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGE
LGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLC
QQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATG
WKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPS
SYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPD
LPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVK
DEATLQAMDEKLRKWKVEL
3D structure
PDB3fvs Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
ChainB
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F125 D213 V215 K247
Catalytic site (residue number reindexed from 1) F122 D210 V212 K244
Enzyme Commision number 2.6.1.64: glutamine--phenylpyruvate transaminase.
2.6.1.7: kynurenine--oxoglutarate transaminase.
4.4.1.13: cysteine-S-conjugate beta-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL B W18 Y101 W15 Y98
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008483 transaminase activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0047316 glutamine-phenylpyruvate transaminase activity
GO:0047804 cysteine-S-conjugate beta-lyase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009617 response to bacterium
GO:0070189 kynurenine metabolic process
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fvs, PDBe:3fvs, PDBj:3fvs
PDBsum3fvs
PubMed19338303
UniProtQ16773|KAT1_HUMAN Kynurenine--oxoglutarate transaminase 1 (Gene Name=KYAT1)

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