Structure of PDB 3fvf Chain B

Receptor sequence
>3fvfB (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
ITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKE
AYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPI
TFSRYIRPISLPAAQASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVP
LISRETCNSLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC
PVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRV
3D structure
PDB3fvf Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
ChainB
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D102
Catalytic site (residue number reindexed from 1) D90
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1JZ B D189 A190 C191 Q192 S195 W215 G216 D217 D188 A189 C190 Q191 S194 W214 G215 D216
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3fvf, PDBe:3fvf, PDBj:3fvf
PDBsum3fvf
PubMed19388054
UniProtQ16651|PRSS8_HUMAN Prostasin (Gene Name=PRSS8)

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