Structure of PDB 3fmi Chain B

Receptor sequence
>3fmiB (length=224) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLA
EVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRP
GRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKL
TLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAA
SLDAGDFAAMSAAAFDRNWVAGLV
3D structure
PDB3fmi Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
ChainB
Resolution2.18 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T11 G12 K15 T16 K37 T41 G54 E108
Catalytic site (residue number reindexed from 1) T10 G11 K14 T15 K36 T40 G53 E107
Enzyme Commision number 6.3.3.3: dethiobiotin synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAP B T11 T41 P71 M72 A73 T10 T40 P70 M71 A72
BS02 KAP B G144 L146 N147 G143 L145 N146
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004141 dethiobiotin synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009102 biotin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fmi, PDBe:3fmi, PDBj:3fmi
PDBsum3fmi
PubMed20565114
UniProtP9WPQ5|BIOD_MYCTU Dethiobiotin synthetase BioD (Gene Name=bioD)

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