Structure of PDB 3fmf Chain B

Receptor sequence
>3fmfB (length=228) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
QSHMTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGD
DDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIAD
LDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLN
HTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALP
AGAASLDAGDFAAMSAAAFDRNWVAGLV
3D structure
PDB3fmf Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T11 G12 K15 T16 K37 T41 G54 E108
Catalytic site (residue number reindexed from 1) T14 G15 K18 T19 K40 T44 G57 E111
Enzyme Commision number 6.3.3.3: dethiobiotin synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DSD B K37 Q40 T41 A73 A110 K40 Q43 T44 A76 A113
BS02 DSD B G144 L146 N147 G147 L149 N150
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004141 dethiobiotin synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009102 biotin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:3fmf, PDBe:3fmf, PDBj:3fmf
PDBsum3fmf
PubMed20565114
UniProtP9WPQ5|BIOD_MYCTU Dethiobiotin synthetase BioD (Gene Name=bioD)

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