Structure of PDB 3fe4 Chain B

Receptor sequence
>3fe4B (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
AHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVN
NGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGEISGSEHTVDGIRHVI
EIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLA
NIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLAD
FVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPN
3D structure
PDB3fe4 Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H111 H113 E125 H138 T220
Catalytic site (residue number reindexed from 1) H53 H79 H81 E90 H103 T185
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B H111 H113 H138 H79 H81 H103
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006730 one-carbon metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:3fe4, PDBe:3fe4, PDBj:3fe4
PDBsum3fe4
PubMed22366092
UniProtP23280|CAH6_HUMAN Carbonic anhydrase 6 (Gene Name=CA6)

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