Structure of PDB 3fe1 Chain B

Receptor sequence
>3fe1B (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQSMELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTD
TERLVGDAAKSQAALNPHNTVFDAKRLIGRKFADTTVQSDMKHWPFRVVS
EGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYLGQPVKHAVITV
PAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVL
IFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFR
RKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTS
ITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKV
QKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGD
3D structure
PDB3fe1 Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D12 S18 F46 T47 K73 E177 D201
Catalytic site (residue number reindexed from 1) D14 S20 F48 T49 K75 E179 D203
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B T16 Y17 G203 G204 G232 E270 K273 R274 S277 G340 G341 R344 D368 T18 Y19 G205 G206 G234 E272 K275 R276 S279 G342 G343 R346 D370
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:3fe1, PDBe:3fe1, PDBj:3fe1
PDBsum3fe1
PubMed20072699
UniProtP17066|HSP76_HUMAN Heat shock 70 kDa protein 6 (Gene Name=HSPA6)

[Back to BioLiP]