Structure of PDB 3fal Chain B

Receptor sequence
>3falB (length=238) Species: 10090 (Mus musculus) [Search protein sequence]
PQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPPQSREARQQRFAHF
TELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYN
PGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFA
LLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB3fal Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
ChainB
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LO2 B L258 A259 S262 M296 T300 F313 F324 I337 H419 L426 W441 L53 A54 S57 M91 T95 F108 F119 I132 H214 L221 W236 MOAD: ic50=165nM
PDBbind-CN: -logKd/Ki=6.78,IC50=165nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3fal, PDBe:3fal, PDBj:3fal
PDBsum3fal
PubMed18800767
UniProtQ9Z0Y9|NR1H3_MOUSE Oxysterols receptor LXR-alpha (Gene Name=Nr1h3)

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