Structure of PDB 3f9z Chain B

Receptor sequence
>3f9zB (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDF
VVEFHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETN
RLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSK
ASIEAHPWLKH
3D structure
PDB3f9z Structural origins for the product specificity of SET domain protein methyltransferases.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F245 E259 C270 M272 Y273 Y274 F275 Q276 Y334 Y336 D338 H347 W349 F54 E68 C79 M81 Y82 Y83 F84 Q85 Y143 Y145 D147 H156 W158
BS02 peptide B L222 S267 L31 S76
BS03 SAH B K226 R228 C270 Y271 L296 N298 H299 Y336 W349 K35 R37 C79 Y80 L105 N107 H108 Y145 W158
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3f9z, PDBe:3f9z, PDBj:3f9z
PDBsum3f9z
PubMed19088188
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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