Structure of PDB 3f7h Chain B

Receptor sequence
>3f7hB (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
GPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFC
YGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIHLTH
3D structure
PDB3f7h Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F81
Catalytic site (residue number reindexed from 1) F4
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C124 C127 H144 C151 C47 C50 H67 C74
BS02 419 B K121 V122 R123 G130 L131 Q132 S133 W134 D138 E143 W147 K44 V45 R46 G53 L54 Q55 S56 W57 D61 E66 W70
External links
PDB RCSB:3f7h, PDBe:3f7h, PDBj:3f7h
PDBsum3f7h
PubMed19228017
UniProtQ96CA5|BIRC7_HUMAN Baculoviral IAP repeat-containing protein 7 (Gene Name=BIRC7)

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