Structure of PDB 3f3y Chain B

Receptor sequence
>3f3yB (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
DFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEI
LCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQ
LFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWF
CQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLG
KTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGD
WKNHFTVAQAEDFDKLFQEKMADLPRELFPWE
3D structure
PDB3f3y rystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K44 H99 S129
Catalytic site (residue number reindexed from 1) K41 H96 S126
Enzyme Commision number 2.8.2.14: bile-salt sulfotransferase.
2.8.2.2: alcohol sulfotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3P B K44 G46 T47 N48 W49 R121 S129 Y184 F220 L245 L246 R247 K248 G249 K41 G43 T44 N45 W46 R118 S126 Y181 F217 L242 L243 R244 K245 G246
BS02 4OA B F18 W72 W77 I82 H99 F133 M137 L234 Y238 F15 W69 W74 I79 H96 F130 M134 L231 Y235
Gene Ontology
Molecular Function
GO:0004027 alcohol sulfotransferase activity
GO:0005515 protein binding
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity
GO:0047704 bile-salt sulfotransferase activity
GO:0050294 steroid sulfotransferase activity
GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding
Biological Process
GO:0006068 ethanol catabolic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0016042 lipid catabolic process
GO:0030573 bile acid catabolic process
GO:0042403 thyroid hormone metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3f3y, PDBe:3f3y, PDBj:3f3y
PDBsum3f3y
PubMed
UniProtQ06520|ST2A1_HUMAN Sulfotransferase 2A1 (Gene Name=SULT2A1)

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