Structure of PDB 3ews Chain B

Receptor sequence
>3ewsB (length=405) Species: 9606 (Homo sapiens) [Search protein sequence]
EDRAAQSLLNKLIRSNLVDNTNQVEVLQRDYSVKSFEELRLKPQLLQGVY
AMGFNRPSKIQENALPLMLPPQNLIAQSQSGTGKTAAFVLAMLSQVEPAN
KYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKIS
EQIVIGTPGTVLDWCSKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQR
MLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYV
LCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVAL
LSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPV
DKDGNPDNETYLHRIGRGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERL
DTDDL
3D structure
PDB3ews The DEXD/H-box RNA Helicase DDX19 Is Regulated by an {alpha}-Helical Switch.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B N69 L70 F112 R114 P115 Q119 S140 G141 T142 G143 K144 T145 N16 L17 F54 R56 P57 Q61 S80 G81 T82 G83 K84 T85
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:3ews, PDBe:3ews, PDBj:3ews
PDBsum3ews
PubMed19244245
UniProtQ9UMR2|DD19B_HUMAN ATP-dependent RNA helicase DDX19B (Gene Name=DDX19B)

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