Structure of PDB 3eto Chain B

Receptor sequence
>3etoB (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
ACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCW
KYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQ
GCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELS
RVLHTNVVFKRDAHGQQMIFPYYGMDVRGSIVYLEIDNRQCVQASSQCFQ
SATDVAAFLGALASLGSLNIPYKIEAVQSETV
3D structure
PDB3eto Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D1458 N1461 V1463 D1476 D1479 D10 N13 V15 D28 D31
BS02 CA B Y1500 D1503 H1505 D1507 D1518 D1521 Y52 D55 H57 D59 D70 D73
BS03 CA B H1540 D1543 H1545 D1547 D1558 D1561 H92 D95 H97 D99 D110 D113
Gene Ontology
Biological Process
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:3eto, PDBe:3eto, PDBj:3eto
PDBsum3eto
PubMed19075186
UniProtP46531|NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (Gene Name=NOTCH1)

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