Structure of PDB 3etj Chain B

Receptor sequence
>3etjB (length=351) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEI
ERWPETALTRQLARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLL
AERSEWPAVFDRLGELAIVKRRTGGGQWRLRANETEQLPAECYGECIVEQ
GINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQA
RAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWTQNGA
SISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLVHLHW
YDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWAQSKF
G
3D structure
PDB3etj Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
ChainB
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E226 E238 N245 S246 K314
Catalytic site (residue number reindexed from 1) E222 E234 N241 S242 K310
Enzyme Commision number 6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B R80 I118 K120 Q131 G155 I156 F158 E161 H184 F228 N237 E238 R80 I118 K120 Q127 G151 I152 F154 E157 H180 F224 N233 E234
BS02 MG B E226 E238 E222 E234
Gene Ontology
Molecular Function
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0034028 5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3etj, PDBe:3etj, PDBj:3etj
PDBsum3etj
PubMed19053251
UniProtP09029|PURK_ECOLI N5-carboxyaminoimidazole ribonucleotide synthase (Gene Name=purK)

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