Structure of PDB 3erd Chain B

Receptor sequence
>3erdB (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL
3D structure
PDB3erd The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
ChainB
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B D545 R548 L549 D233 R236 L237
BS02 peptide B I358 K362 V376 E380 E542 I54 K58 V72 E76 E230
BS03 DES B M343 E353 M421 H524 L525 M39 E49 M117 H212 L213 BindingDB: Ki=0.128000nM,IC50=0.330000nM,EC50=0.110000nM
External links
PDB RCSB:3erd, PDBe:3erd, PDBj:3erd
PDBsum3erd
PubMed9875847
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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