Structure of PDB 3epz Chain B

Receptor sequence
>3epzB (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
GRFQGPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNELPQHKLTCFSV
YCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDEGGVNGKNLGPINEWW
ITKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSD
STYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDQP
IFLTPCMRDLIKLAGVTLGQRRA
3D structure
PDB3epz The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
ChainB
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C353 C356 H418 C8 C11 H56
External links
PDB RCSB:3epz, PDBe:3epz, PDBj:3epz
PDBsum3epz
PubMed21389349
UniProtP26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

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