Structure of PDB 3epp Chain B

Receptor sequence
>3eppB (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
RIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKK
GRINKLVCTDIADVSVKQCQQRYEDMKNRYIFSAEFITADSSKELLIDKF
RDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNS
FELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEDVPEFLVY
FPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQLPLGTLSK
SEWEATSIYLVFAFEKQQ
3D structure
PDB3epp Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin.
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG B K17 G42 D64 I65 D98 S99 Q121 F122 V123 M137 K13 G38 D60 I61 D90 S91 Q113 F114 V115 M129
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping

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Molecular Function
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Biological Process
External links
PDB RCSB:3epp, PDBe:3epp, PDBj:3epp
PDBsum3epp
PubMed
UniProtO43148|MCES_HUMAN mRNA cap guanine-N7 methyltransferase (Gene Name=RNMT)

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