Structure of PDB 3enh Chain B

Receptor sequence
>3enhB (length=485) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MICLGLEGTAEKTGVGIVTSDGEVLFNKTIMEAADHHAETFPKLIKEAFE
VVDKNEIDLIAFSQGPGLGPSLRVTATVARTLSLTLKKPIIGVNHCIAHI
EIGKLTTEAEDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAVGNCLDQF
GPYIEELARKGKKLVDLPYTVKGMDIAFSGLLTAAMRAYDAGERLEDICY
SLQEYAFSMLTEITERALAHTNKGEVMLVGGVAANNRLREMLKAMCEGQN
VDFYVPPKEFCGDNGAMIAWLGLLMHKNGRWMSLDETKIIPNYRTDMVEV
NWIEADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLAL
VKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDNLDIAYKIGEIVG
KLHKNDVIHNDLTTSNFIFDKDLYIIDFGLGKIEDKAVDLIVFKKAVLST
HHEKFDEIWERFLEGYKSVYDRWEIILELMKDVER
3D structure
PDB3enh Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TBR B M1 H297 K298 M1 H276 K277
BS02 TBR B E11 N156 E11 N145
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005506 iron ion binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006338 chromatin remodeling
GO:0006400 tRNA modification
GO:0006468 protein phosphorylation
GO:0008033 tRNA processing
GO:0016310 phosphorylation
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
Cellular Component
GO:0000408 EKC/KEOPS complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3enh, PDBe:3enh, PDBj:3enh
PDBsum3enh
PubMed18951093
UniProtQ58530|KAE1B_METJA Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein (Gene Name=MJ1130)

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